Pretty in PINK1, Cryo-EM Reveals How Kinase Anchors to …
Mar 14, 2025 · A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led …
Cryo-EM structures of amyloid-β 42 filaments from human brains ...
Jan 18, 2022 · The cryo-EM analysis focuses on fibrils that are relatively “clean,” and a large fraction of the fibril segments end up being discarded. Therefore, the relative abundances in …
New Type of Aβ42 Fibril Discovered in 83-Year-Old Man
Jul 1, 2025 · For starters, a new fibril type may complicate the interpretation of amyloid PET scans. Using cryo-EM, the researchers found that 18 F-florbetapir sits in a narrow channel …
Cryo-EM structure of Alzheimer disease tau filaments with
Sep 28, 2023 · This preprint by Kunach et al. describes a beautiful 2.1 Å resolution cryo-EM structure of PHFs from the frontal cortex of an individual with sporadic Alzheimer’s disease in …
Structure of human PINK1 at a mitochondrial TOM-VDAC array
Mar 14, 2025 · This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized at the TOM complex, and Komander and his …
In Lipoparticles, ApoE Double Belt Keeps the Fat In - ALZFORUM
Feb 1, 2024 · Cryo-EM brought the complexes into slightly sharper focus, supporting the idea that α-helical chains of ApoE wrap in opposite directions around the discs, like frosting piped …
Caught in the Act: Cryo-EM Exposes γ-Secretase Catalytic Pose
Jun 7, 2024 · Cryo-EM resolves γ-secretase complexed with APP-C99, Aβ46, Aβ49, and Aβ43. During processing, an α-helix unwinds by one turn, while a three-residue β-strand positions it …
Spooned by a Fold: MK-6240 Nestles Within Tau Protofilament
Sep 28, 2023 · Cryo-EM resolved structure of MK-6240 bound to tau. The ligand bound to the inner cavity of each C-shaped protofilament. Stacked MK-6240 molecules interact more with …
That Mystery “Density” in α-Syn Fibrils: Polyphosphate, Anyone?
Nov 8, 2024 · For now, the nature of the additional densities in cryo-EM reconstructions of brain-derived filaments therefor remains a mystery. To demonstrate what the densities are made of, …
Molecular mechanism of substrate recognition and cleavage by
Jun 7, 2024 · Using cryo-EM of γ-secretase bound to APP-C99, Aβ49, Aβ46, and Aβ43, we are presented with the greatest insight yet of the sequential generation of Aβ species. The work …