A small-molecule ligand that binds to a (CAG) n hairpin repeat is the basis of a biosensor to detect repeat length, which may help diagnose trinucleotide repeat disease severity. DNA trinucleotide ...
When CAG nucleotide triplets repeat excessively in a gene called huntingtin, a devastating and currently untreatable neurodegenerative “repeat expansion disorder” arises called Huntington’s Disease ...
Armed with base editors, scientists from the laboratory of David Liu, PhD, professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, and their ...
The inheritance of mutated version of either BRCA1 or BRCA2 confers a high risk of developing breast cancer. However, only 10-20 % of the breast cancer families carries BRCA mutations, suggesting the ...
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