MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...

In a study that appears in the journal Cell, scientists from San Francisco-based Gladstone Institutes—including co-first author Megan Ostrowski (left) and senior author Vijay Ramani, PhD ...

A team of researchers has generated one of the most detailed 3D maps of human chromosomes, cataloging over 140,000 DNA looping interactions.

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and ...

“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...

The ability to extract trace bits of DNA from soil, water, and even air is revolutionizing science. But it's not foolproof. In the late 1980s, at a federal research facility in Pensacola, Florida, ...